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Sagiri Isose Selected Research

mecobalamin (methylcobalamin)

1/2022Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.
12/2018The Japanese Early-Stage Trial of High-Dose Methylcobalamin for Amyotrophic Lateral Sclerosis (JETALS): Protocol for a Randomized Controlled Trial.
1/2014Safety and efficacy of intravenous ultra-high dose methylcobalamin treatment for peripheral neuropathy: a phase I/II open label clinical trial.

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Sagiri Isose Research Topics

Disease

7Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
01/2022 - 04/2008
3Neuralgia (Stump Neuralgia)
10/2018 - 12/2009
3Pain (Aches)
10/2018 - 12/2009
3Fasciculation (Fasciculations)
02/2012 - 04/2008
2POEMS Syndrome (Syndrome, POEMS)
10/2015 - 08/2012
2Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
10/2015 - 11/2009
2Demyelinating Diseases (Demyelinating Disease)
10/2015 - 08/2012
2Polyneuropathies (Polyneuropathy)
06/2010 - 11/2009
1Parkinson Disease (Parkinson's Disease)
01/2021
1Edema (Dropsy)
10/2015
1Neuroinflammatory Diseases
01/2015
1Alzheimer Disease (Alzheimer's Disease)
01/2015
1Dementia (Dementias)
01/2015
1Tauopathies
01/2015
1Multiple Myeloma
02/2014
1Peripheral Nerve Injuries
01/2014
1Peripheral Nervous System Diseases (PNS Diseases)
01/2014
1Paraproteinemias (Monoclonal Gammopathy)
08/2012
1Paralysis (Palsy)
01/2011
1monomelic Amyotrophy
01/2011
1Paresthesia (Dysesthesia)
05/2010
1Hyperglycemia
12/2009

Drug/Important Bio-Agent (IBA)

3mecobalamin (methylcobalamin)IBA
01/2022 - 01/2014
3SodiumIBA
10/2015 - 05/2010
2Biomarkers (Surrogate Marker)IBA
01/2021 - 08/2012
2AutoantibodiesIBA
01/2021 - 12/2018
2PotassiumIBA
10/2015 - 12/2011
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/2015 - 08/2012
2CytokinesIBA
10/2015 - 08/2012
2Proteins (Proteins, Gene)FDA Link
08/2012 - 03/2011
2Potassium Channels (Potassium Channel)IBA
12/2011 - 01/2011
1Complementary DNA (cDNA)IBA
01/2021
1ImmunosorbentsIBA
01/2021
1Proteasome Endopeptidase Complex (Proteasome)IBA
12/2018
1Inosine Monophosphate (IMP)IBA
10/2018
1Duloxetine Hydrochloride (Cymbalta)FDA Link
10/2018
1Immunoglobulins (Immunoglobulin)IBA
10/2015
1Adrenal Cortex Hormones (Corticosteroids)IBA
10/2015
1Cholinergic Antagonists (Anticholinergics)IBA
01/2015
1Cholinergic Agents (Cholinergics)IBA
01/2015
1Bortezomib (Velcade)FDA Link
02/2014
1Proteasome InhibitorsIBA
02/2014
1Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric
01/2014
1Interleukin-12 (IL 12)IBA
08/2012
1SuspensionsIBA
08/2012
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
08/2012
1Interleukin-6 (Interleukin 6)IBA
08/2012
1DNA-Binding Proteins (DNA Binding Protein)IBA
03/2011
1Sodium-Potassium-Exchanging ATPase (Sodium, Potassium ATPase)IBA
01/2011
1Lidocaine (Xylocaine)FDA LinkGeneric
05/2010
1Mexiletine (Mexitil)FDA LinkGeneric
05/2010
1Hemoglobins (Hemoglobin)IBA
12/2009
1polyolIBA
12/2009
1rho-Associated KinasesIBA
11/2009
1polyglutamineIBA
04/2008

Therapy/Procedure

2Therapeutics
10/2018 - 01/2014
2Plasmapheresis
10/2015 - 06/2010
2Denervation
02/2012 - 04/2008
1Tracheostomy
01/2022
1Aftercare (After-Treatment)
10/2018
1Glycemic Control
12/2009